COX-2 inhibitors are a special class of NSAIDs that
block the body's production of a substance that causes inflammation and pain.
They are less likely to cause stomach ulcers and gastrointestinal bleeding
than other NSAIDS. COX-2 inhibitors are much more expensive than standard NSAIDs
like ibuprofen. Celecoxib (Celebrex) is a COX-2 inhibitor.
Possible side effects
COX-2 inhibitors can cause the following side effects:
- Heart attack and stroke. Several COX-2s have been taken off the market
due to the risk of fatal and non-fatal cardiovascular events. The FDA asked
the manufacturer of Celebrex to place a strong warning on its label to alert
patients to the potential for such risks.
- Stomach pain and diarrhea.
- Poor kidney function, especially if you are over 65 years old. If you develop
fluid build up, notify your doctor right away.
- Negative interactions with medications for high blood pressure, heart disease,
and seizures. Make sure that the doctor prescribing COX-2 inhibitors knows
about all of the other drugs you are taking.
People who should not use COX-2
If you are allergic to NSAIDs, sulfa drugs, or aspirin, you cannot take COX-2
inhibitors. Also, if you are pregnant or planning to become pregnant in the
near future, you should not use COX-2 inhibitors.
If you had a heart attack or have a history of blockages in your coronary
arteries, ask your doctor if COX-2s are right for you. People with a history
of other heart conditions or risk factors, such as diabetes, high blood pressure,
or high cholesterol, should use COX-2 inhibitors with caution.
US Food and Drug Administration. FDA Public Health Advisory: FDA Announces
Important Changes and Additional Warnings for COX-2 Selective and Non-Selective
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Rockville, MD: Center
for Drug Evaluation and Research; April 7, 2005.
Review Date: 4/6/2007
Reviewed By: Benjamin D. Roye, M.D., M.P.H., Orthopaedic
Surgery, The Mount Sinai Hospital, New York, NY. Review provided by VeriMed Healthcare
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997-
A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.