Drug treatments: Other drug therapies

Although used less frequently than other cholesterol-lowering medications, there are times when other drug treatments, such as fibrates, may be appropriate.

Fibrates

The cholesterol-lowering drugs called fibrates are primarily effective in lowering triglycerides and, to a lesser extent, increasing HDL (good) cholesterol levels.

Medications in this class include fenofibrate (Antara, Lofibra, Tricor, Triglide) and gemfibrozil.

Fibrates are generally not considered first- or even second-choice drugs for lowering cholesterol, because they are not very effective at lowering LDL cholesterol. They are used when help is needed to bring down triglycerides, often in combination with other cholesterol-lowering medications that do lower LDL cholesterol.

Fibrates have been shown to lower triglycerides by 20 -50% and to increase HDL cholesterol by 10 - 15%.

The most common side effects include gastrointestinal symptoms (including stomach pain, diarrhea, nausea, vomiting, and constipation) and an increased risk of developing gallstones.

Fibrates can increase the effect of medications that thin the blood (such as warfarin). Your health care provider should monitor this closely, as well as your liver function, which may be affected by fibrates.

When fibrates are taken together with statins, there is an increased risk of muscle tissue breakdown and kidney failure. The safety and effectiveness of fibrates in children is not known.

 

Main Menu


Review Date: 10/31/2006

Reviewed By: Alan Greene, M.D., F.A.A.P., Department of Pediatrics, Packard Children's Hospital, Stanford University School of Medicine; Chief Medical Officer, A.D.A.M., Inc.


The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

adam.com

Related Links

Find a Cardiac Specialist:

-

Physicians

-

Surgeons

Request an Appointment Online or call
1-800-789-PENN (7366)
Penn Heart and Vascular
Encyclopedia Articles about the Heart

 

   
   

 

About Penn Medicine   Contact Us   Site Map   Privacy Statement   Legal Disclaimer   Terms of Use

Penn Medicine, Philadelphia, PA 800-789-PENN © 2014, The Trustees of the University of Pennsylvania space