B-cell leukemia/lymphoma panel is a test that looks for certain proteins on the surface of white blood cells called B-lymphocytes. The proteins serve as markers that may be helpful in diagnosing leukemia or lymphoma.

B lymphocyte cell surface markers

A blood sample is needed. Blood is drawn in the following way:

• The site is cleaned with germ-killing medicine (antiseptic).
• The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
• The health care provider gently inserts a needle into the vein.
• The blood collects into an airtight vial or tube attached to the needle.
• The elastic band is removed from your arm.
• The needle is removed.
• The puncture site is covered to stop any bleeding.

In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. Afterward, a bandage may be placed over the area if there is any bleeding.

In some cases, white blood cells are removed during a bone marrow biopsy. The sample may also be taken during a lymph node biopsy or other biopsy when lymphoma is suspected.

The blood sample is sent to a laboratory, where a specialist checks the cell type and characteristics. This procedure is called immunophenotyping. The test is usually done using a technique called flow cytometry.

No special preparation is usually necessary.

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

This test may be performed:

• When other tests (such as a blood smear) show signs of abnormal white blood cells
• When leukemia or lymphoma is suspected
• To find out the type of leukemia or lymphoma

• B-cell lymphocytic leukemia
• Lymphoma

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

• Excessive bleeding
• Fainting or feeling light-headed
• Hematoma (blood accumulating under the skin)
• Infection (a slight risk any time the skin is broken)

This special test may not be available at all laboratories.

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