There are several different types of biopsies.
A needle biopsy is called a percutaneous biopsy. It removes tissue using a hollow tube called a syringe. The needle is passed several times through the tissue being examined. The surgeon uses the needle to remove the tissue sample. Needle biopsies are often done using CT scan or ultrasound. These imaging tools help guide the surgeon to the right area.
An open biopsy is surgery that uses local or general anesthesia. This means you are relaxed (sedated) or asleep and pain-free during the procedure. It is done in a hospital operating room. The surgeon makes a cut into the affected area, and the tissue is removed.
Closed biopsy uses a much smaller surgical cut than open biopsy. A small cut is made so that a camera-like instrument can be inserted. This instrument helps guide the surgeon to the right place to take the sample.