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Macroglobulinemia of Waldenstrom


Definition:

Macroglobulinemia of Waldenstrom is a cancer of the B lymphocytes (a type of white blood cell). It is associated with the overproduction of proteins called IgM antibodies.

Alternative Names:

Waldenstrom macroglobulinemia; Macroglobulinemia - primary; Lymphoplasmacytic lymphoma

Causes:

Waldenstrom macroglobulinemia is a result of a condition called lymphoplasmacytic lymphoma. What causes too much production of the IgM antibody is unknown. Overproduction of IgM causes the blood to become too thick. This is called hyperviscosity. It can make it harder for blood to flow through small blood vessels.

Waldenstrom macroglobulinemia is very rare. Most people with this condition are over age 65, but it may occur in younger people.

Symptoms:

Symptoms may include any of the following:

Exams and Tests:

A physical examination may reveal a swollen spleen, liver, and lymph nodes. An eye exam may show enlarged veins in the retina or retinal bleeding (hemorrhages).

A CBC shows a low number of red blood cells and platelets. A blood chemistry shows evidence of kidney disease. A serum viscosity test can tell if the blood has become thick. Symptoms usually occur when the blood is four times thicker than normal.

A test called serum protein electrophoresis shows an increased level of the IgM antibody. Levels are often higher than 3 grams per deciliter (g/dL).

Bone lesions are very rare. If they are present, a bone marrow examination will show cells that resemble both lymphocytes and plasma cells.

Additional tests that may be done:

Treatment:

Plasmapheresis removes unwanted substances from the blood. In macroglobulinemia, it removes or reduces the high level of IgM, and is used to quickly control the symptoms caused by blood thickening.

Drug therapy may include corticosteroids or combinations of chemotherapy drugs.

Patients who have a low number of red or white blood cells or platelets may need transfusions or antibiotics.

Outlook (Prognosis):

The average survival is about 6.5 years. Some people live more than 10 years.

In some persons, the disorder may produce few symptoms and progress slowly.

Possible Complications:

When to Contact a Medical Professional:

Call your health care provider if symptoms of this disorder develop.

References:

National Cancer Institute: PDQ Adult Non-Hodgkin Lymphoma Treatment. Bethesda, MD. National Cancer Institute. Date last modified 4/11/2014. Available at http://www.cancer.gov/cancertopics/pdq/treatment/adult-non-hodgkins/HealthProfessional. Accessed June 9, 2014.

Rajkumar SV. Plasma cell disorders. In: Goldman L, Schaer AI, eds. Goldman's Cecil Medicine. 23rd ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 193.


Review Date: 6/9/2014
Reviewed By: Todd Gersten, M.D., Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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