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Acute adrenal crisis


Definition:

Acute adrenal crisis is a life-threatening condition that occurs when there is not enough cortisol. This is a hormone produced by the adrenal glands.

Alternative Names:

Adrenal crisis; Addisonian crisis; Acute adrenal insufficiency

Causes:

The adrenal glands are located just above the kidneys. The adrenal gland consists of two parts. The outer portion, called the cortex, produces cortisol. This is an important hormone for controlling blood pressure. The inner portion, called the medulla, produces adrenaline (also called epinephrine). This is a hormone released in response to stress.

Cortisol production is regulated by the pituitary gland. This is a small gland behind the nose and under the brain. The pituitary gland releases adrenocorticotropic hormone (ACTH). This is a hormone that causes the adrenal glands to release cortisol.

Adrenaline production is regulated by nerves coming from the brain and spinal cord and by circulating hormones.

Adrenal crisis occurs when:

  • The adrenal gland is damaged due to, for example, Addison disease or other adrenal gland disease, surgery
  • The pituitary gland is injured and cannot release ACTH
  • Adrenal insufficiency is not properly treated

Risk factors for adrenal crisis include:

  • Dehydration
  • Infection and other physical stress
  • Injury to the adrenal or pituitary gland
  • Stopping treatment too suddenly with glucocorticoid medications such as prednisone or hydrocortisone
  • Surgery
  • Trauma
Symptoms:

Symptoms of adrenal crisis can include any of the following:

Exams and Tests:

Tests that may be ordered to help diagnose acute adrenal crisis include:

Treatment:

In adrenal crisis, patients need an immediate injection of hydrocortisone through a vein (intravenous) or muscle (intramuscular). You may receive intravenous fluids if you have low blood pressure.

You will need to go to the hospital for treatment and monitoring. If infection or another medical problem caused the crisis, you may need additional treatment.

Outlook (Prognosis):

Shock may occur if treatment is not provided early, and it can be life-threatening.

Possible Complications:
When to Contact a Medical Professional:

Call your health care provider if you have Addison disease and are unable to take your glucocorticoid medicine for any reason.

Go to the emergency room or call the local emergency number (such as 911) if you develop symptoms of acute adrenal crisis.

If you have Addison disease, you may be told to increase the dosage of your glucocorticoid medicine if you are very ill or before having surgery.

Prevention:

If you have Addison disease, learn to recognize signs of potential stress that may cause an acute adrenal crisis. If you have been instructed by your doctor, be prepared to give yourself an emergency shot of glucocorticoid or to increase your dosage of oral glucocorticoid medication in times of stress.

Always carry medical ID (card, bracelet, or necklace) that says you have adrenal insufficiency. The ID should also say the type of medicine and dosage you need in case of an emergency.

Never miss taking your medicines.

References:

Chaker AJ, Vaidya B. Addison disease in adults: diagnosis and management. Am J Med. 2010;123:409-413.

Stewart PM, Krone NP. The adrenal cortex. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 15.


Review Date: 11/7/2013
Reviewed By: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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