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Mesothelioma - malignant


Definition:

Malignant mesothelioma is an uncommon cancerous tumor of the lining of the lung and chest cavity (pleura) or lining of the abdomen (peritoneum) that is typically due to long-term asbestos exposure.

Alternative Names:

Malignant mesothelioma

Causes, incidence, and risk factors:

Long-term exposure to asbestos -- a fire-resistant material -- is the biggest risk factor. Asbestos was once commonly found in insulation, ceiling and roofing vinyls, cement, and automotive brake materials. Although many asbestos workers smoked, experts do not believe smoking itself is a cause of this condition.

Malignant mesothelioma affects men more often than women. The average age at diagnosis is 60. Most appear to develop the condition about 30 some years after being in contact with the asbestos.

Symptoms:

Symptoms may not appear until 20 - 50 years or longer after exposure to asbestos, and may include:

Signs and tests:

Mesotheliomas are often hard to diagnose under the microscope. It can be hard to distinguish between this disease and similar conditions and tumors.

Treatment:

Malignant mesothelioma is a difficult cancer to treat.

There is usually no cure, unless the disease is found extremely early and the tumor can be completely removed with surgery. However, most of the time at diagnosis, the disease is too advanced for surgery. Chemotherapy or radiation may be used to reduce symptoms. Combining certain chemotherapy drugs may help decrease symptoms, but it will not cure the cancer.

Untreated, the average malignant mesothelioma patient survives 9 months.

Consider participating in a clinical trial (test of new treatments), which may give you more treatment options.

Pain relief, oxygen, and other supportive treatments may also help relieve symptoms.

Support Groups:

You can ease the stress of illness by joining a support group where members share common experiences and problems.

See:

Expectations (prognosis):

The average survival time varies from 4 - 18 months. However, your outlook depends on:

  • The stage of the tumor
  • Your age and general health
  • Whether surgery is an option
  • Your response to treatment
Complications:

The tumor can quickly spread to other organs.

Calling your health care provider:

Call for an appointment with your health care provider if you have symptoms of malignant mesothelioma.

Prevention:

Avoid exposure to asbestos.

References:

Ettinger DS. Lung cancer and other pulmonary neoplasms. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 197.

National Comprehensive Cancer Network. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Malignant pleural mesothelioma. 2012. Version 2.2012.


Review Date: 6/5/2012
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

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